These embrace adjustments in bone turnover and in fee of restore, in addition to lack of connectivity of the trabecular components that comprise cancellous bone. At menopause, the speed of bone loss accelerates sharply. The essential years for constructing bone mass start in preadolescence. Whole lifetime losses might equal 30 to forty % of peak mass for girls and 20 to 30 p.c for males.Bone loss could happen in both trabecular or cor. Peak bone mass happens at about age 20 for the hip and through the early thirties for the spine. Osteoclasts resorb bone and osteoblasts synthesize new bone matrix.